Pues tiene el QS-21, en colaboración con GSK...
QS-21 STIMULON® ADJUVANT
Agenus’ proprietary QS-21 Stimulon® is believed to be one of the most potent adjuvants known. QS-21 Stimulon is a saponin extracted from the bark of the Quillaja saponaria (soap bark) evergreen tree native to warm temperate central Chile and purified using Agenus’ proprietary process. The adjuvant has been widely studied in over 120 clinical trials involving approximately 50,000 healthy volunteers and patients, and has consistently demonstrated powerful immune responses and a favorable safety profile
QS-21 Stimulon® is a key component in several GSK vaccines, including the most efficacious shingles vaccine, Shingrix®, which has demonstrated >90% efficacy, as well as the first ever malaria vaccine, Mosquirix®. QS-21 Stimulon® improves a vaccine’s effectiveness by inducing strong antibody and cell-mediated immune responses. It also plays a key role by boosting immune response in older adults who often experience age related decline in immunity. In October 2017, the U.S. Food and Drug Administration (FDA) granted marketing authorization to GSK for Shingrix® for the prevention of shingles in adults aged 50 years and older. The Center for Disease Control and Prevention recently declared Shingrix® as the preferred shingles vaccine for approximately 62 million eligible adults in the United States. As a result, Shingrix® revenues have exceeded expectations, tripling analyst estimates for 2018, its first year of commercial sales. GSK has forecast that annual revenues will exceed $600M in 2018 – comparable to the $668M in revenues generated by Zostavax in 2017 after >10 years on the market. Additionally, in 2017, the World Health Organization announced that Mosquirix® will be made available to select African countries as a prophylactic measure targeted for young children.
Adding QS-21 Stimulon® with our vaccines give us critical advantages:
- Mutation-targeting vaccines often impart CD4 “helper” T cell responses. QS-21 Stimulon® generates both CD4 helper and CD8 killer T cell responses;
- QS-21 Stimulon® activates the innate immune system which is a critical partner to the adaptive (T cell-based) immune response to cancer;
- In pre-clinical studies, the combination of HSP, peptides and QS-21 stimulates a potent memory response which is necessary for vaccine efficacy.
In September 2015, Agenus partially monetized its potential royalty stream from GSK through a $100M non-dilutive royalty transaction
with an investor group led by Oberland Capital. In January 2018, Agenus repurchased the obligation from Oberland and sold the royalty stream outright to HealthCare Royalty Partners.
"In January 2018, we and our wholly-owned subsidiary, Antigenics LLC (“Antigenics”), entered into a Royalty Purchase Agreement with Healthcare Royalty Partners III, L.P. and certain of its affiliates (together, “HCR”), pursuant to which HCR purchased 100% of Antigenics’ worldwide rights to receive royalties from GSK on sales of GSK’s vaccines containing our QS-21 Stimulon adjuvant. As consideration for the purchase of the royalty rights, HCR paid $190.0 million at closing, less certain transaction expenses. Of the closing proceeds, approximately $161.9 million was used to redeem Antigenics’ $115.0 million principal amount of notes issued pursuant to the Note Purchase Agreement with Oberland Capital SA Zermatt LLC, and we retained approximately $28.0 million of net proceeds. Antigenics is also entitled to receive up to $40.35 million in milestone payments based on sales of GSK’s vaccines as follows: (i) $15.1 million upon reaching $2.0 billion last-twelve-months net sales any time prior to 2024 and (ii) $25.25 million upon reaching $2.75 billion last-twelve-months net sales any time prior to 2026. Antigenics will owe approximately $25.9 million to HCR in 2021 if neither of the following sales milestones are achieved: (i) 2019 sales of GSK’s vaccines exceed $1.0 billion or (ii) 2020 sales of GSK’s vaccines exceed $1.75 billion (the “Rebate Payment”). As part of the transaction, we provided a guaranty for the potential Rebate Payment and secured the obligation with substantially all of our assets, other than our equity interest in our subsidiary AgenTus Therapeutics, pursuant to a security agreement. If GSK’s sales do not achieve either of the relevant milestones and we are obligated to make the Rebate Payment, our liquidity could be materially and adversely affected. "